In the present study, we observed repressed c-Myc and enhanced FOXO1 transactivity in GNA13-silenced GC cells, and increased c-Myc and decreased FOXO1 transactivity in GNA13-transduced GC cells, which was associated with alterations in the expression of cell cycle inhibitors (p21Cip1 and p27Kip1) and the CDK regulators (cyclin D1), suggesting that GNA13-induced proliferation and tumorigenesis might be due to modulation of c-Myc and FOXO1 activity. This evidence concerns the gene CCND1 and gastric cancer.