To determine the molecular mechanism underlying EDIL3-mediated anchorage-independent growth of PDAC cells, we detected the effect of EDIL3 on the expression of Bcl-2 family proteins, including Bcl-2, Bcl-xL and Bax, which have been demonstrated to be important for tumor growth and anoikis resistance [22, 23]. Here, BCL2L1 is linked to neoplasm.