For example, in breast cancer cells, miR-31 targets frizzled3 (Fzd3), integrin α-5 (ITGA5), myosin phosphatase-Rho-interacting protein (M-RIP), matrix metallopeptidase 16 (MMP16), radixin (RDX), and the ras homolog gene family member A (RhoA) [16, 22, 27]. This evidence concerns the gene RHOA and breast carcinoma.