Accumulating evidence shows that the reprogramming of tumor metabolism is controlled by various oncogenic signals [4], such as RAS, AKT, MYC, PI3K, mTOR, together with tumor suppressors, including TP53 and PTEN, which alter metabolism and allow cancer cells to survive and proliferate in the hypoxic and nutrient-deprived tumor microenvironment. This evidence concerns the gene PTEN and neoplasm.