To confirm that the observed proteome alterations were not cell-specific, ENO1 was also silenced in two other pancreatic cancer cell lines (PT45 and T3M4) as well as in a breast and a lung tumor cell line (MDA-MB-231 and NCI-H441, respectively) (Supplementary Figure S1B–S1E). The gene discussed is ENO1; the disease is familial pancreatic carcinoma.