Impressively, Mejias and Fernandez recently confirmed that mTOR blockade by rapamycin led to a dramatic regression of splenomegaly and a significant decrease of mesenteric pathological angiogenesis in a non-cirrhotic PHT model [7, 16], indicating the close relevance of mTOR signaling pathway in the pathophysiology of splenomegaly with chronic PHT. This evidence concerns the gene MTOR and pulmonary hypertension, primary, 1.