Some authors have regarded itmerely as a disease marker.13Interestingly, Levy et al.18described the case of a lupus patient in which the appearance of severe RP wasassociated with the emergence of high titer anti-RNP seroconversion, suggestingthat these autoantibodies may play a role in the pathogenesis of peripheralischemic attacks. This evidence concerns the gene RNPC3 and systemic lupus erythematosus.