APP and Alzheimer disease: Indeed, in the case of dietary depletion, the PSEN1 promoter can become hypomethylated in TgCRND8 – harboring the Swedish and V717F Indiana APP mutations (Chishti et al., 2001) – and APPswe/PS1dE9 AD models (Fuso et al., 2011; Li et al., 2015).