Similarly, in Tg2576 AD mice – harboring the Swedish APP mutation in combination with the M146V PSEN1 mutation which results in higher levels of Aβ formation (Chishti et al., 2001) – the global levels of H4 acetylation are not altered, but when mice are subjected to learning and memory paradigms only wild-type animals are able to increase the levels of histone acetylation and not the Tg2576 mice (Francis et al., 2009). Here, APP is linked to Alzheimer disease.