Equally relevant seems to be the hypermethylation of the gene Insulin-Like Growth Factor Binding Protein 7 (IGFBP7), which is sustained by consistent changes in DNA methylation in the APPPS1-21 AD mouse model – harboring the Swedish APP mutation in combination with the L166P PSEN1 mutation (Radde et al., 2006) – and in human frontal cortex samples (Agbemenyah et al., 2014). Here, PSEN1 is linked to Alzheimer disease.