MET and esophageal squamous cell carcinoma: L1 hypomethylation is associated with poor prognosis of lung adenocarcinoma (Ikeda et al., 2013), hepatocellular carcinoma via activation of c-Met (Zhu et al., 2014), esophageal squamous cell carcinoma (ESCC; Iwagami et al., 2013), and with inferior survival in colorectal carcinomas with high microsatellite instability (Inamura et al., 2014).