RNASEL and ovarian carcinoma: Downregulation of L1 mRNA and subsequently, reduced expression of the ORF1p and ORF2p by RNase L was also shown to restrict L1 mobilization; whereas, siRNA-mediated knockdown of endogenous RNase L lead to a significant increase in L1 retrotransposition events in a human ovarian cancer cell line (Zhang et al., 2014).