Systematic search from PubMed was performed using the key terms included “cancer,” “carcinoma,” “tumor,” “neoplasm,” “methylation,” “hypermethylation,” “hypomethylation,” “demethylation,” “TERT,” and “telomerase reverse transcriptase.” In total, 290 articles were identified from PubMed search (Figure S1 in Supplementary Material). This evidence concerns the gene TERT and neoplasm.