Such studies have led to describing important roles of mutant p53 in direct inhibition of the p63/p73-mediated tumor suppression (28, 29), activation of the cell cycle drivers, such as Cyclins (30, 31), the vitamin D3 receptor signaling (32), steroid synthesis (mevalonate pathway) (33), the ID4-mediated angiogenesis (34), or nucleotide homeostasis (26), to name a few. Here, TP53 is linked to neoplasm.