TP53 and neoplasm: p53 mutant proteins are stabilized and protected from degradation in a tumor microenvironment by various oncogenic signaling pathways (16, 17), and several studies in mutant p53 knock-in (KI) mice showed that the presence of p53 mutants promotes tumor growth with higher metastasis rate and different tissue spectrum than the absence of wild-type p53 (12, 18).