ANXA5 and cancer: However, when the two NRPs were combined, a significant induction of Annexin V staining in the cancer cells was observed with a mean value of 25.5% Annexin V positive cells relative to the control treatment (Fig. 6A), which included an increase in both early (i.e., 22.8% Annexin V+, PI−) and late (i.e., 3.9% Annexin V+, PIdim/bright) apoptotic cells (Fig. 6B).