CD4 and Autoimmunity: Again, we did not observe any modification in the capacity of T cells to mediate autoimmunity that could have been caused by the lack of S100A4 expression and mice adoptively transferred with S100a4Gfp/Gfp CD4+ T cells developed EAE to the same extent as those receiving S100a4+/+ CD4+ T cells (Fig. 6C).