Clinical and experimental analyses have identified a central role for IgE/FcεR/mast cells and mast cell‐derived mediators, including histamine, platelet‐activating factor (PAF), serotonin, proteases (tryptase and chymase), lipid‐derived mediators (prostaglandins [PGD2] and leukotrienes [LTC4, LTD4, and LTE4]), in promoting the clinical manifestations associated with food‐triggered anaphylaxis 9, 10, 11, 12, 13, 14, 15. This evidence concerns the gene IGHE and anaphylaxis.