SPAG16 and myeloid sarcoma: In MS, different antibody targets have been described, including myelin basic protein (MBP), myelin oligodendrocyte glycoprotein (MOG), neurofilament, sperm-associated antigen 16 (SPAG16), coronin-1a, heat shock proteins, and other components of the CNS, emphasizing the diversity and complexity of the antibody response (45–54).