For example, in HIV positive cases there is reported increase in C. glabrata, followed by C. krusei; in insulin using diabetes mellitus patients’ significant percentage of C. dubliniensis and C. glabrata was noted; also certain mucosal lesions, oral cancer and elderly hospitalized patients have shown increase in NCAC species carriage (Gutierrez et al., 2002). This evidence concerns the gene INS and diabetes mellitus.