TARDBP and Alzheimer disease: Also, among people with late-onset AD, autopsy studies highlight the frequent co-occurrence of other brain pathologies, such as vascular changes (macro-infarcts, lacunes and micro-infarcts, amyloid angiopathy, arteriosclerosis, and microbleeds) and other protein aggregates (e.g., alpha-Synuclein and TDP43) (17, 18).