Another refinement, single molecule arrays (SIMOA), which divides samples into microwells and allows higher detection of signal to background, has been used to identify changes in plasma Aβ in patients who had experienced cardiac arrest (89) and increases in serum or plasma levels of tau in professional athletes after concussion (90), in combat-related traumatic brain injury (TBI) (91), and in patients with major brain trauma (92). Here, MAPT is linked to brain injury.