This stimulation results in contraction of cytoplasmic actin filaments and redistribution of TJs anchoring protein, ZO-1 and structural protein, occludin in IBD (Crohn's disease, ulcerative disease), leaky flux diarrhea, and cholera (watery diarrhea; Zolotarevsky et al., 2002; Utech et al., 2005; Schwarz et al., 2007; Marchiando et al., 2010; Qasim et al., 2014). The gene discussed is PROS1; the disease is inflammatory bowel disease.