However, we took advantage of the knock-down of this protein to assess the consequences of constitutive Cx43 deficiency in a set of behavioral aspects known to be affected in depression: hedonic state, behavioral despair, self-care, anxiety, and cognition/memory by comparing Cx43fl/fl mice and Cx43wt/wt mice maintained on the same genetic background. Here, GJA1 is linked to major depressive disorder.