Other studies investigating levels of soluble RAGE (sRAGE), a natural competitor of RAGE, in ALS and AD showed a correlation between low levels of plasma sRAGE and the clinical and pathophysiological manifestation of these diseases (Emanuele et al., 2005; Ilzecka, 2009; Liang et al., 2013). This evidence concerns the gene AGER and amyotrophic lateral sclerosis.