AGER and amyotrophic lateral sclerosis: The observed increase in expression of RAGE binding AGEs, such as CML, reported previously in the spinal cord of ALS patients (Shibata et al., 1999, 2000; Kikuchi et al., 2002), further implicates AGE-RAGE contribution to the ALS pathogenesis, potentially via neuroinflammation and oxidative stress mediation of neuronal damage.