One of the first association of depression with altered miRNAs was described for P2RX7 (purinergic receptor P2x, ligand-gated ion channel 7) gene, where single nucleotide polymorphisms (SNPs) were identified in putative miRNA target sites of miR-1302 and miR-625 within the P2RX7 3′-untranslated region (Rahman et al., 2010). The gene discussed is P2RX7; the disease is major depressive disorder.