NFKB1 and Alzheimer disease: In recent years, NF-κB dysregulation has been shown to link to neurodegenerative mechanisms that occur in brain during trauma or ischemia (Bethea et al., 1998; Schneider et al., 1999), as well as in the brain of patients suffered by PD (Hunot et al., 1997; Ghosh et al., 2007) or AD (Boissiere et al., 1997; Kaltschmidt et al., 1997; Lukiw and Bazan, 1998).