At least three Crh-Cre mouse lines have been reported, and have been used to demonstrate roles for CRF neurons in fear conditioning (Gafford et al., 2014), fear extinction (Gafford et al., 2012), anxiety and avoidance behaviors (Gafford et al., 2012; McCall et al., 2015), and binge-like alcohol consumption (Pleil et al., 2015). The gene discussed is CRH; the disease is Anxiety.