CHD8 and autism: In total, 16 de novo CHD8 mutations (0.46%, Poisson 95% CI: 0.26–0.75%) were identified in the SSC and TASC cohorts, both of which required probands to meet ASD criteria on the Autism Diagnostic Interview-Revised (ADI-R) and Autism Diagnostic Observation Schedule (ADOS; Lord et al., 1994, 1999).