SOD1 and amyotrophic lateral sclerosis: ALS mice that carry both the G93A mSOD1 mutation and a reduced amount of EAAT2 (SOD1(G93A)/EAAT2±) exhibited an increase in the rate of motor decline accompanied by earlier motor neuron loss when compared with single mutant G93A mSOD1 Tg mice (Pardo et al., 2006).