In triple transgenic AD mice expressing the amyloid precursor protein mutations K670N and M671L, the presenilin 1 mutation M146V and the tau P301L mutation (Oddo et al., 2003; Zumkehr et al., 2015), a strong and age-dependent reduction of EAAT2 expression was found (Zumkehr et al., 2015). The gene discussed is MAPT; the disease is Alzheimer disease.