As described in the Section on “The Concepts of Acute and Chronic Glutamate Toxicity,” homozygous EAAT2 knock-out mice suffer from premature death due to epilepsy and show hippocampal and focal cortical atrophy (Tanaka et al., 1997; Kiryk et al., 2008; Petr et al., 2015). The gene discussed is SLC1A2; the disease is epilepsy.