It also induced EAAT2 expression in the spinal cords of wild-type and mutant G93A mSOD1 Tg mice, which was associated with a decrease in motor neuron loss, weight loss, and other ALS-like symptoms and an increase in survival (Rothstein et al., 2005), compatible with the idea that EAAT2 loss contributes to chronic excitotoxicity in this mouse model. This evidence concerns the gene SLC1A2 and amyotrophic lateral sclerosis.