WNK2 and Alzheimer disease: The pathophysiology of AD is complex and many pathways are involved in the synaptic and cellular degeneration in AD including abnormalies in signaling pathways via glycogen synthase kinase-3 beta or mitogen-activated protein kinases, cell cycle re-enty (reviewed by Majd et al., 2015), oxidative stress (reviewed by Niedzielska et al., 2015), or decreased transport of trophic factors and mitochondrial dysregulation (reviewed by Overk and Masliah, 2014).