STRADα has been identified as the gene responsible for the autosomal recessive neurodevelopmental disorder polyhydramnios, megalencephaly, and symptom epilepsy syndrome (PMSE), which is characterized by macrocephaly, craniofacial dismorphism, hypotonica, cognitive disability, and intrac epilepsy (Puffenberger et al., 2007). The gene discussed is STRADA; the disease is polyhydramnios, megalencephaly, and symptomatic epilepsy.