STRADA and polyhydramnios, megalencephaly, and symptomatic epilepsy: These results suggests that STRADα-Stk25-LKB1- mTORC1 signaling, may regulate radial neuronal migration in addition to its role in polarity formation (Matsuki et al., 2010, 2013) and also suggests that hyperactivation of mTORC1 signaling by STRADα gene mutation affect the cortical development at an early stage in human PMSE (Figure 3).