To study whether human RPS23RG1 may be involved in AD, we checked and found that RPS23RG1 mRNA levels in frontal cortex were significantly reduced in brain samples from AD patients (Supplementary Table S1) but not from Parkinson’s disease patients (Fig. 2A), suggesting that the reduction of RPS23RG1 expression may be specific to AD. This evidence concerns the gene RPS23P1 and Alzheimer disease.