Consistent with this finding, overexpression of both human RPS23RG1 and mouse Rps23rg1 increased levels of inactive phosphorylated GSK-3 in mouse neuroblastoma N2a cells stably expressing the human APP Swedish mutation (N2aSwe), while total GSK-3 levels were unchanged (Fig. 3D). The gene discussed is RPS23P1; the disease is neuroblastoma.