The culmination of all of these studies come to light with the finding of several (some reported and many from our group still publication pending) Laron’s Syndrome (congenital IGF-1 deficiency or GH insensitivity) never treated patients who underwent progression to MetS and ultimately to T2D together with diabetic retinopathy when they reached their late 30 s, [250, 251]. Here, GH1 is linked to metabolic syndrome.