INS and Insulin resistance: 2007), we also investigated SNAP23 colocalization with LDs. SNAP23 only showed a weak partial colocalization with LDs (Fig. 3B). It cannot be excluded though that colocalization of SNAP23 with LDs is more prevalent in insulin‐resistant individuals in line with the hypothesis that LDs hijack SNAP23 in obese individuals (Sollner 2007) and patients with type 2 diabetes (Bostrom et al. 2010) thereby reducing plasma membrane SNAP23 and contributing to the development of skeletal muscle insulin resistance.