In contrast to cHL, Reed-Sternberg and Hodgkin (RSH) cells are rarely seen in NLPHL, and immunohistochemistry shows a different pattern on the malignant cells; RSH cells typically express CD15 and CD30, whereas LP cells lack expression of these markers, but express B cell markers like CD20, CD22, and CD79a and also express the common leukocyte antigen CD45, which is uncommon on RSH cells [4]. The gene discussed is PTPRC; the disease is classic Hodgkin lymphoma.