CRYGD and nuclear cataract: By directly sequencing the coding region of CRYGD, we identified a recurrent (p.P24T) mutation in two unrelated families with congenital coralliform cataracts and three novel (p.Q101X, p.E104fsX4 and p.E135X) mutations in three families with congenital nuclear cataracts (Figs 1 and 2).