FSHB and hypogonadism: Rare mutations in the FSHB gene cause truncation of the FSH-β protein and result in hypogonadism and primary amenorrhoea in females (Layman et al., 1997; Matthews and Chatterjee, 1997; Kottler et al., 2010) and, in a male, delayed puberty with azoospermia (Phillip et al., 1998).