NSC652287 (RITA: reactivation of p53 and induction of tumor cell apoptosis) is also identified through cell proliferation assay-based screening using isogenic cell lines of HCT116 (wild-type p53 and p53-null) as a compound that suppresses the growth of HCT116 (wild-type p53) cells in a dose-dependent manner with minimum effects on HCT116 (p53-null) cells (56). The gene discussed is TP53; the disease is neoplasm.