GADD45A and cancer: Later, NSC652287/RITA was found to suppress the growth of cancer cell lines carrying various p53 mutants (p53R175H, p53R213Q/Y234H, p53R248W, p53R248Q, p53I254D, p53R273H, and p53R280K) by restoration of p53 transcriptional activity (p21, NOXA, PUMA, and GADD45) and induction of apoptosis through upregulation of pro-apoptotic proteins and downregulation of several oncogenes or anti-apoptotic proteins (32, 33, 57).