Indeed, NSC319726 [zinc metallochaperone-1 (ZMC1)], a thiosemicarbazone derivative, was identified in a screen of the NCI60 panel of human tumor cell lines as a compound that exhibited selective toxicity to cells carrying p53R175H with minimum effects on cells expressing wild-type p53 and other p53 mutants (p53R248Q and p53R273H) (35). This evidence concerns the gene TP53 and neoplasm.