TP53 and neoplasm: SCH529074 restores the PAb1620 epitope by acting as a chaperone and enhances DNA-binding activity of several p53 mutants (p53R175H, p53S241F, p53R248W, p53R249S, and p53R273H), leading to upregulation of p53 downstream target genes (p21, BAX, NOXA, cyclin G1, and PUMA), induction of proliferation arrest or apoptosis, and inhibition of in vivo tumor growth of mutant p53-expressing cell lines (41).