BTRC and neoplasm: Phosphorylation of the 376HXRXXpS381 motif by the Lats tumour suppressor provides the priming signal for CK1δ/ɛ to phosphorylate the neighbouring 383DpSGXpS387 phosphodegron in Yes-associated protein and enables recognition by β-TRCP, the substrate recognition subunit of SCFβ-TRCP.