In AD, neuroinflammation is associated with an increase of activated complement proteins and cytokines, such as interleukin 6 (IL-6) and monocyte chemotactic protein-1 (MCP-1; also referred to as chemokine (C-C motif) ligand 2 (CCL2)), and activated microglia and astrocytes [4, 5]. This evidence concerns the gene CCL2 and Alzheimer disease.