Finally, among those patients with non-systemic JIA and no history of CAU (n = 88), a majority switched to a second anti-TNF therapy (n = 63) (the vast majority had received etanercept as their first biologic), although there were also children who switched to abatacept, tocilizumab, anakinra and rituximab (Fig. 3). This evidence concerns the gene TNF and juvenile idiopathic arthritis.