Figure 2A showed the expression of EGFP in the CA1 of rats. The analysis of the Western blot data using one-way ANOVA revealed that SIRT6 expression in the CA1 was significantly increased 10 days after lentivirus infection in the group infused with LVSIRT6-GFP (198.2 ± 15.1%) compared with the group infused with LVGFP (100 ± 2.1%) in the CA1 (F1,9 = 41.412, p < 0.0001, ES = 2.035; Fig. 2C and Fig. S2). No significant differences were found in the protein levels of SIRT1 or SIRT2 in the CA1 region (all p > 0.05; Fig. 2C). Here, SIRT6 is linked to lentivirus infection.