Furthermore, evaluation of HIF-1α stabilization by pharmacological inhibition of prolyl hydroxylases, namely the HIF-1-specific PHD inhibitor AKB-4924, have revealed an important role for HIF-1α in boosting the innate immune response of keratinocytes against skin infections [92] and of the intestinal epithelium in murine colitis [93]. Here, SETD2 is linked to colitis.