We found that blood levels of FOXP3+ Tregs (-2.5 ± 0.56, p<0.001) and eTregs (-1.3±0.6, p = 0.03) were lower in patients with severe liver (HF++ or HF+++) and spleen (SplM) disease who had undergone splenectomy (Fig 2A and 2C) than in HF+++ subjects with splenomegaly. The gene discussed is FOXP3; the disease is Splenomegaly.