CXCR3 and chronic hepatitis C virus infection: Helbig et al. [32] reported that the CXCR3 chemokines were the most strongly expressed chemokines in the livers of patients with chronic hepatitis C. Others have more directly implicated Foxp3+ Tregs in protection against chronic hepatitis: in a model of autoimmune inflammation of the liver, Lapierre et al. [33] observed that the adoptive transfer of ex vivo-expanded CXCR3+ Tregs in mice with auto-immune hepatitis deficiency resulted in targeting to the inflamed liver and the restoration of peripheral tolerance, inducing a remission of auto-immune disease.