In lymph node metastasis-positive group, the 5-year OS and DFS rates of the Tenascin-C-positive group (positive expression in stroma and cancer, respectively) were also significantly lower than those of the Tenascin-C-negative group (in addition to OS rate of the stroma-Tenascin-C- positive group) (S3 Fig). Here, TNC is linked to metastatic malignant neoplasm in the lymph nodes.