Furthermore, lymph node metastasis occurred more frequently when ESCC stromal fibroblasts showed positive expressions of both Tenascin-C and PDGFRβ (p = 0.038), Tenascin-C and SMA (p = 0.038), Tenascin-C and FAP (p < 0.001), Tenascin-C and FSP1 (p = 0.014), than when stromal fibroblasts were negative of both Tenascin-C and CAF markers (S2B–S2F Fig). Here, TNC is linked to esophageal squamous cell carcinoma.