In the univariate Cox regression analysis, the following factors were independent poor prognostic factors of both OS and DFS (Table 2): ESCC differentiation (p = 0.022 and p = 0.046, respectively), clinical stage (p < 0.001 and p < 0.001, respectively), Tenascin-C expression status (Tenascin-C in cancer cells: p = 0.002 and p = 0.004, respectively; Tenascin-C in stromal fibroblasts: p < 0.001 and p < 0.001, respectively), and TAM numbers (p = 0.001 and p = 0.002, respectively). The gene discussed is TNC; the disease is esophageal squamous cell carcinoma.