In particular, the 5-year OS and DFS rates of the patients with positive Tenascin-C expression in both cancer cells and stromal fibroblasts (20.0% and 18.0%, respectively) were significantly lower than those of the patients who showed positive Tenascin-C expression in either of the cell types (positive expression in only cancer cells: 83.3% and 70.8%, respectively; positive expression in only stromal fibroblasts: 58.1% and 41.9%, respectively) or those who showed negative expression in both the cell types (94.7% and 89.5%, respectively; OS: p < 0.001; DFS: p < 0.001; Fig 4). Here, TNC is linked to cancer.