The use of pharmacological tools to mimic or revert Arf6 function at synapse opens new therapeutic approaches to correct dysregulations of the Arf6 pathway occurring in human neurological diseases associated with mutations in the Arf6 regulatory genes (Shoubridge et al., 2010; Falace et al., 2010; Rauch et al., 2012; Fine et al., 2015). Here, ARF6 is linked to nervous system disorder.