This report is a part of parent study (under review) of an antidepressant response to an adjuvant PPAR-γ agonist, Pioglitazone, in patients with unremitted depression.19 Here we aimed to assess LTL as a predictor of antidepressant response to Pioglitazone in groups of IR and insulin-sensitive (IS) subjects using surrogate markers of IR. This evidence concerns the gene PPARG and depressive disorder.