PTGS2 and nervous system disorder: Several genes central in the network, such as APP, PTGS2, ERG and YWHAG were found to be linked to Root 66 genes, and have been implicated in processes such as amyloid plaque formation, astrocytosis and gliosis, cognitive degeneration and neurological dysfunction typical of neurological diseases including Parkinson's, Alzheimer's and Schizophrenia.