It has not been defined whether higher-calorie-expenditure exercises (45 to 60 min per session, almost daily walking) are more effective than short distance walking (25 to 40 min, few times per week, or multiple exercise modalities) in alleviating psychotic symptoms.78 We suggest that protein supplementation be tested in controlled studies, as a strategy to correct hyperinsulinemia and restoring tPA activity. The gene discussed is PLAT; the disease is hyperinsulinism.