SPARC and colorectal cancer: In colorectal cancer, SPARC expression in MSC (HR, 0.654; CI,0.409–1.048; p = 0.028; HR, 0.536; CI, 0.359–0.802; p = 0.002) were all independent prognostic factors for OS and DFS, respectively, and the low expression of SPARC was also related with the high level of TNM[10].