In spite of the apparent lack of immune reactivity against the four HLA-A*02:01/HLA-DRB1*01:01 binding immunogenic peptides in influenza challenged mice, we speculated if T cells from immunized mice with specificity for the double restricted peptides (Figs 1 and 2), might still be capable of killing directly infected cells and thereby lower the virus titre. Here, HLA-DRB1 is linked to influenza.