Moreover, in contrast to the cell-intrinsic function of type I IFNs in monocyte migration described above (Fig 2D), we found that the percentage of CD11b+Ly6CloLy6G+ neutrophils was comparable among CD45.1+ WT and CD45.2+Ifnar1—/—compartments before (S4 Fig) and following (Fig 5D) infection, suggesting that type I IFNs regulate neutrophil migration through a cell-extrinsic manner. This evidence concerns the gene ITGAM and infection.