AKT1 and hepatocellular carcinoma: Interestingly, we found that inhibiting PI3K/Akt signaling in 14-3-3β-overexpressing cells by LY294002 suppressed the activation of NF-κB signaling pathway (Fig 4F), implying 14-3-3β promotes HCC cells migration and invasion via PI3K/Akt/NF-κB pathway.