An earlier study reported that Snail can selectively interacted with14-3-3γ, 14-3-3ε, 14-3-3τ, 14-3-3η and 14-3-3β in MCF breast cancer cells and 293T cells, and such interaction represses the expression of E-cadherin and further triggers EMT [25]. This evidence concerns the gene SNAI1 and breast carcinoma.