Our present study demonstrates that the endogenous PPAR-α ligand, OEA, can significantly suppress the pro-fibrotic cytokine TGF-β1 negatively regulate genes in the TGF-β1 signaling pathway (α-SMA, collagen 1a, and collagen 3a) in mice models of hepatic fibrosis. This evidence concerns the gene ACTA1 and Hepatic fibrosis.