DPM1 and Global developmental delay: Identical phenotypes were observed for both MOs and dpm1 morphants recapitulated most features of congenital disorder of glycosylation type 1e (CDG1e) associated with DPM1 mutations, including developmental delay, microcephaly, ocular defects and vascular anomalies, which were fully evident at 2–3 days post fertilization (d.p.f.; Fig. 4f and Supplementary Fig. 15d,e)9.