The IR subtype shows up-regulation of a range of lymphoid signalling molecules at the mRNA level (e.g. TGFBR2, IL11RA, TNFRSF17, CCL15, CCL14, CCR2, CD27, XCL2, IFNAR2, CD40LG are the 10 most up-regulated genes in the cytokine-cytokine receptor interaction pathway), suggesting alterations in either the composition or functional activity of immune cells within these tumours. This evidence concerns the gene XCL2 and neoplasm.